NUT Expression In Primary Lung Tumours
NUT midline carcinoma: an aggressive intrathoracic neoplasm. J Thorac Oncol. 2013;8:1335–8. 12. French C. NUT midline carcinoma. Nat Rev Cancer. 2014;14:149–50. 13. Sholl LM, Nishino M, Pokharel S, Mino-Kenudson M, French CA, Janne PA, et ... Fetch Doc
The Department Of Pathology Training Program In The French ...
The Department of Pathology training program in the French Lab, which focuses on a rare, childhood cancer called NUT midline carcinoma, is designed to train people in clinical research, molecular biology and cancer cell biology techniques, ... Visit Document
BRD4 Is An Atypical Kinase That Phosphorylates Serine2
BRD4 is an atypical kinase that phosphorylates Serine2 of the RNA Polymerase II carboxy-terminal domain Ballachanda N . Devaiah3 NUT midline carcinoma, colon cancer, and inflammatory disease (2- 7). It suppresses tumor metastasis in mice, and its expression is a prognostic signature of ... Read Full Source
Disruption Of BRD4 At H3K27Ac-enriched Enhancer Region ...
NUT midline carcinoma (NMC). Moreover, an oncogenic BRD4-NUT fusion gene driven by BRD4 promoter is found in NMC and other types of human cancers.8 Furthermore, inhibi-tion of BET bromodomain by small-molecule compounds with ... Retrieve Full Source
BRD4-1 GST Bromodomain
BRD4-1 (GST) (Bromodomain containing protein 4, bromodomain 1) CATALOG NO.: NUT midline carcinoma10. Selective inhibitors of BRD4/BET family bromodomains 1-3 are showing promise as possible therapeutic agents for cancer,14 6 and ... View This Document
Novel BRD4/JAK2 Dual Inhibitors As Cancer Therapeutics
Molecules that inhibit BRD2-4 and BRD3-4 for hematologic malignancies, NUT midline carcinoma, and advanced solid cancers. At least one inhibitor, OncoEthix’s OTX015, has successfully completed Phase I clinical studies, suggesting that inhibition of BRD4 is not deleterious. ... Fetch Doc
Case Report First Evidence Of Treatment Efficacy In Metastatic ...
Keywords: Nut midline carcinoma, Chemotherapy, BRD4/NUT fusion gene Introduction Nuclear protein in testis (NUT) germline carcinomas (NMCs), genetically defined by rearrangements of NUT, first came to attention after two reports in ... Fetch This Document
BRD4-1 (His) (Bromodomain Containing Protein 4, Bromodomain 1)
BRD4-1 (His) (Bromodomain containing protein 4, bromodomain 1) CATALOG NO.: Chromosomal translocations that produce BRD4-NUT fusion proteins are implicated in causation of a rare and aggressive cancer, NUT midline carcinoma10. ... Read Content
Edited Transcript Of CRIS Earnings Conference Call Or Presentation 9-Nov-15 1:30pm GMT
Q3 2015 Curis Inc Earnings Call ... Read News
New Developments In The Molecular Pathogenesis Of Head And ...
Including mucoepidermoid carcinoma (MEC), adenoid cystic carcinoma (ACC), and NUT midline carcinoma (NMC). The t(11;19)(q12;p13) translocation in MEC results in fusion of the MECT1 gene at 19p13 and the MAML2 gene at 11q21. ... Access Doc
Small Round Cell Tumors Of Bone And Soft Tissue, Part 2 (non ...
• NUT translocation carcinoma –Midline head, neck, and upper thorax location • Extrarenal rhabdoid tumor –Any location, favors “paraxial” sites –Age important –History of previous rhabdoid tumors 3 . Other round cell sarcomas of bone ... Read Here
SPENCER COMMUNITY SCHOOLS COMMON SCHOLARSHIP APPLICATION 2015
Cancer called NUT Midline Carcinoma. The last 6 weeks of his life he spent in hospitals and grew much appreciation for the numerous nurses he had. There are always those patients that a nurse will never forget, but ... Access Full Source
Lathan , Edward B. Stelow 5, Sonja C. Lüer 6, Somala Muhammed ...
4 ABSTRACT Purpose NUT midline carcinoma (NMC) is a poorly differentiated squamous cancer characterized by rearrangement of the NUT gene. Research advances have ... Visit Document
Staging And Post-Surgical Restaging Multimodality Approach To ...
8. Evans AG, French CA, Cameron MJ, Fletcher CD, Jackman DM, Lathan CS, Sholl LM: Pathologic characteristics of NUT midline carcinoma arising in the mediastinum. ... Doc Retrieval
Degree(s): Title(s): Building Location: Fax: Research Interests
Differentiation!of!NUT!Midline!Carcinoma!by!Epigenomic!Reprogramming.!Cancer!Res.!2011!Apr!1;71(7):2686B96.! Future Research Directions / Areas Looking For Scientific Synergies: We!have!performed!exome!sequencing!on!a!number!(10)!of!NUT!midline!carcinomas,!and!would!like!to!collaborate!with! ... Read Here
JQ1 - Wikipedia, The Free Encyclopedia
Interest in JQ1 as a cancer therapeutic stemmed from its ability to inhibit BRD4 and BRD3, both of which form fusion oncogenes that drive NUT midline carcinoma. ... Read Article
BRD4 Antibody - Cell Signaling Technology
Against nuclear protein in testis (NUT) midline carcinoma cell lines and xenografts in mice where BRD4 is found to be a frequent translocation partner of the NUT protein (12). In addition, BRD4 regulates the expression of some inflamma- ... Retrieve Doc
Stephanie Doyle Grady 1981- 2014 PEI - YouTube
Prince Edward Islander Stephanie Doyle Grady was diagnosed with an rare form cancer called nut midline carcinoma. She had been accepted to take part in clinical trials in Boston to treat the disease. She passed away Saturday. A very sad day, indeed. ... View Video
Chicagopathology.org
However, sinonasal undifferentiated carcinoma (SNUC) and NUT midline carcinoma (NUT) cannot be differentiated with only H&E stain and regular IHC When NUT midline carcinoma is suspected, the confirmatory tests including FISH and RT-PCR should be performed. ... Read Full Source
BRD4 Is An Atypical Kinase That Phosphorylates Serine2 Of The ...
BRD4 is an atypical kinase that phosphorylates Serine2 of the RNA Polymerase II carboxy-terminal domain Ballachanda N. Devaiaha, NUT midline carcinoma, colon cancer, and in-flammatory disease; its loss is a prognostic signature for meta- ... Fetch Full Source
IDENTIFICATION OF POTENT BROMODOMAIN4 (BRD4) INHIBITORS BY ...
IDENTIFICATION OF POTENT BROMODOMAIN4 (BRD4) INHIBITORS BY ENERGY-PHARMACOPHORE BASED VIRTUAL SCREENING TO TARGET BRD4-NUT MIDLINE CARCINOMA SAPAM TULESHWORI DEVI, groups to be linked to a rare form of cancer called BRD4-NUT midline carcinoma. ... Access Document
Immunohistochemical Analysis Of Paraffin-embedded Normal ...
NUT midline carcinoma (NMC) is a recently recognized cancer that is defined by the presence of chromosomal rearrange-ments involving the NUT gene on chromosome 15q14 (3). In most cases the chromosomal translocation occurs ... Retrieve Here
A Nutty Case Of Squamous Cell Carcinoma?
Discussion NUT Midline Carcinoma (NMC) is a rare variant of squamous cell carcinoma, defined by a rearrangement of the NUT gene. Usually found in younger adults in the midline (upper aerodigestive ... Document Viewer
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